During the last Grant Period, we recognized the importance of separate WG1 & 3 meetings to push forward novel multimodal pipelines in so-called showcase pipelines. This requires bringing together experts in diverse fields to work jointly on a biomedical research questions that will be tackled by correlative multimodal imaging including data integration and analysis. We plan to organize specific meetings for this, close to a laboratory which is already proactively imaging such a sample. AIm is to discuss our current showcase pipelines, analysis of previously implemented modalities, adjacent lab visits and sample exchange, and coordination of further steps. Developing a showcase project for CLEM & go beyond the established approaches, thus pushing the limits of CLEM. The meeting aims at setting up a pipeline that involves superresolution, which requires a broad expertise from diverse imaging scientists. Topics to coordinate and plan are (including the involvement of computational approaches and WG4): LGA-PEG Nanoparticles with STORM dyes encapsulated, incubated in MCF7 cells (breast cancer cell line, as Biliana is working with anticancer drugs for breast cancer). Live cell imaging (Confocal or SIM?). Fixation (controversial step!). Single molecule localization microscopy (STORM). Cryo fixation/resin embedding. Cryo-TEM/TEM. Image alignment